Publications

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New Publication !!!

Clarbruno Vedruccio e Carla Ricci
Noninvasive radiofrequency diagnostics of cancer. The Bioscanner ―Trimprob technology and clinical applications,

Journal of Physics: Conference Series, Vol. 329, 012038, 2011.
Relazione al 9th International Fröhlich’s Symposium, Electrodynamic Activity of Living Cells (EDALC11) , Praga 2011.

http://iopscience.iop.org/1742-6596/329/1

online: LINK

 

Jiri Pokorny; Clarbruno Vedruccio; Michal Cifra, PhD.; Ondrej Kucera, Cancer physics: Diagnostics based on damped cellular elasto electrical vibrations in microtubules (European Biophysics Journal)
2011 March 10

online: LINK

Scientific publications related to the diagnostic system
BIOSCANNER TRIMPROB divided in groups
 

  •  First publication:

    • C.Vedruccio and A.Meessen, EM Cancer Detection by Means of Non Linear Resonance Interaction, Proceedings of PIERS 2004, Progress in Electromagnetics Research Simposium, Pisa, Italy, March 28-31 2004 : 909-912.
      EM Cancer Detection by Means of Non Linear Resonance Interaction: doc\Vedruccio-Meessen PIERS 2004.pdf  
      Il principio fisico del BIOSCANNER: doc\Fisica in Medicina 2004.pdf    
       
    • A.Meessen: Working Principle of an EM Cancer Detector; Institut de Physique, Université Catholique de Louvain, Louvain-la-Neuve, Belgium (2004) Cfr. Sito Web: http://www.meessen.net/AMeessen/EMcancerDet2.pdf  

      Working Principle of an EM Cancer Detector, August Meessen, Institut de Physique, Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium: doc\Meessen EMcancerDet2.pdf 

 

  •   SCIENTIFIC BACKGROUND:
     

    C.Vedruccio and A.Meessen, EM Cancer Detection by Means of Non Linear Resonance Interaction, Proceedings of PIERS 2004, Progress in Electromagnetics Research Simposium, Pisa, Italy, March 28-31 2004 : 909-912.
     

    • Fricke, H. and Morse, S. The electric capacity of tumors of the breast, J. Cancer Res. 10, 340-376, 1926.
      doc\Fricke-Morse 1926.pdf  
       

    • Joines, W.T., Jurtle, R.L., Rafal, M.D. and Schaeffer, D.J. Microwave power absorption differences between normal and malignant tissue, Int. J. Radiol. Oncology Biol. Phys. 6, 681-7 (1980).
      doc\Joines 1980.pdf  

 

  •   THE SCIENTIFIC PAPER:  
    • Jiri  Pokorny*;  Clarbruno  Vedruccio;  Michal  Cifra,  PhD.;  Ondrej  Kucera, Cancer  physics:  Diagnostics  based on  damped  cellular  elastoelectrical  vibrations  in  microtubules  (European Biophysics Journal)  

    European Biophysics Journal
    Online First™ Articles available before print publication
    ORIGINAL PAPER
    Cancer physics: diagnostics based on damped cellular elastoelectrical vibrations in microtubules
    Jiří Pokorný, Clarbruno Vedruccio, Michal Cifra and Ondřej Kučera
    Online First™, 2011 March 10

    http://www.springerlink.com/content/577757274043rk07/

    *Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic , Praga.

    Abstract
    This paper describes a proposed biophysical mechanism of a novel diagnostic method for cancer detection developed recently by Vedruccio. The diagnostic method is based on frequency selective absorption of electromagnetic waves by malignant tumors. Cancer is connected with mitochondrial malfunction (the Warburg effect) suggesting disrupted physical mechanisms. In addition to decreased energy conversion and nonutilized energy efflux, mitochondrial malfunction is accompanied by other negative effects in the cell. Diminished proton space charge layer and the static electric field around the outer membrane result in a lowered ordering level of cellular water and increased damping of microtubule-based cellular elastoelectrical vibration states. These changes manifest themselves in a dip in the amplitude of the signal with the fundamental frequency of the nonlinear microwave oscillator—the core of the diagnostic device—when coupled to the investigated cancerous tissue via the near-field. The dip is not present in the case of healthy tissue.
    Keywords Cancer diagnostics – Bioscanner® TRIMprob™ – Physical processes in cancer – Biological electromagnetic field – Water ordering in cells – Nonlinear resonance interaction (NLRI)
     

    • Non-thermal effects and mechanisms of interaction between electromagnetic fields and living matter. a cura di L. Giuliani, M. Soffritti
Clarbruno Vedruccio: Polarizability of normal and cancerous tissues, a Radiofrequency Nonlinear Resonance Interaction non invasive diagnostic Bioscanner Trimprob detector alle pagg.177-185.

doc\Eur.J. Oncol 2010-0.pdf

 

  •  Clinical trials papers on PUBMED (Database of the National Institute of Health U.S.A., medical publications with impact factor) to see the abstracts site: http://www.ncbi.nlm.nih.gov/pubmed/ (Search: Trimprob)

    • Alberto Vannelli, Luigi Battaglia, Elia Poiasina and Ermanno Leo, Diagnosis of rectal cancer by Tissue Resonance Interaction Method, BMC Gastroenterology 2010, 10:45.
      Division of General Surgery B, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
      http://www.biomedcentral.com/1471-230X/10/45
      doc\TRIM Rectal Cancer 2010.pdf
      PUBMED IN PROGRESS

       
    • Di Viccaro D, Perugia G, Cerulli C, Olivieri V, Bova J, Zanza C, Teodonio S, Liberti M. 
      The accuracy of tissue resonance interaction method probe (Trimprob tm) in non-invasive diagnosis of prostatic cancer. Analysis of the results of 782 
      patient. 
      Urologia. 2009;76 Suppl 15:1-3. PubMed PMID: 21104675.
      doc\2009 Di Vaccaro-Cerulli Riv_Urologia_.pdf
       
    • O. Gokce, O. Sanli, A. Salmaslioglu, A. Tunaci, C. Ozsoy and F. Ozcan, Tissue Resonance Interaction Method (TRIMprob) has the potential to be used alongside the recognized tests in the screening protocols for prostate cancer, International Journal of Urology (Int J Urol.), 2009 Jun;16(6):580-3.
      doc\Int J Urol Turch 2009.pdf  
      (Clinical Trials carried out at The Departments of Urology and Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey)
       
    • Vannelli A, Leo E, Battaglia L, Poiasina E., Diagnosis of rectal cancer by electromagnetic interactions: preliminary results, Dis Colon Rectum. 2009 Jan;52(1):162-6. (Clinical Trials carried out at Istituto Nazionale dei Tumori - National Cancer Institute - Milan Italy)
      doc\Ist Tum Mi Trimprob-rectal cancer 2009.pdf   
       
    • Tubaro A, De Nunzio C, Trucchi A, Stoppacciaro A, Miano L., The electromagnetic detection of prostatic cancer: evaluation of diagnostic accuracy. Urology. 2008 Aug;72(2):340-4. (Clinical Trials carried out at The Sapienza University – Sant'Andrea Hospital Roma Italy)
      doc\TRIMprob Urology 2008.pdf     
       
    • Sacco R, Sammarco G, De Vinci R, Vescio G, Scarpelli A, Lucisano AM, Pata F, Mascia E, Martines V.,Relief of gastric cancer with an electromagnetic interaction system (TRIMprob) in outpatients. Chir Ital. 2007 Nov-Dec;59(6):823-8. (Clinical Trials carried out at Magna Graecia-University– Mater Domini Hospital– Catanzaro Italy)
       
    • Da Pozzo L, Scattoni V, Mazzoccoli B, Rigatti P, Manferrari F, Martorana G, Pietropaolo F, Belgrano E, Prezioso D, Lotti T, Villari D, Nicita G.,Tissue-resonance interaction method for the noninvasive diagnosis of prostate cancer: analysis of a multicentre clinical evaluation. BJU Int. 2007 Nov;100(5):1055-9. (Five University Multicentre Clinical Trials carried out at: S.Raffaele Milan, Federico II Naple, Careggi Florence, S.Orsola-Malpighi Bologna, Cattinara Trieste - Italy)
       
    • Gervino G, Autino E, Kolomoets E, Leucci G, Balma M., Diagnosis of bladder cancer at 465 MHz. Electromagn Biol Med. 2007;26(2):119-34. (Clinical Trials carried out at Vito Fazzi Hospital – Lecce Italy)
       
    • Sacco R, Innaro N, Pata F, Lucisano AM, Talarico C, Aversa S.,Preoperative diagnosis of incidental carcinoma in multinodular goitre by means of electromagnetic interactions Chir Ital. 2007 Mar-Apr;59(2):247-51. (Clinical Trials carried out at Magna Graecia-University– Mater Domini Hospital– Catanzaro Italy)
       
    • De Cicco C, Mariani L, Vedruccio C, Ricci C, Balma M, Rotmensz N, Ferrari ME, Autino E, Trifirò G, Sacchini V, Viale G, Paganelli G., Clinical application of spectral electromagnetic interaction in breast cancer: diagnostic results of a pilot study. Tumori. 2006 May-Jun;92(3):207-12. (Clinical Trials carried out at The European Institute of Oncology – I.E.O.- Milan Italy)
      http://www.tumorionline.it/index.php?archivio=yes&vol_id=234   
      doc\Breast IEO Tumori 2006.pdf
       
    • Bellorofonte C, Vedruccio C, Tombolini P, Ruoppolo M, Tubaro A., Non-invasive detection of prostate cancer by electromagnetic interaction., Eur Urol. 2005 Jan;47(1):29-37; discussion 37. (Clinical Trials carried out at the San Carlo Hospital - Milan Italy)
      doc\Eur Urol 2005.pdf   
  •  Physics and Biophysics  papers relative to the  principles of operation: 

    • C. Vedruccio, A. Meessen, Nuove possibilità diagnostiche tramite onde elettromagnetiche, Fisica in Medicina (AIFM), 3: 225-230, 2004C.
       
    • Vedruccio, Ultra High Frequency and Microwave Non-linear Interaction Device for Cancer Detection and Tissue Characterization, Proc. of Augmented Reality in Surgery, 1st European Summer School (ARISER) IFC-CNR , Lecce, Italy, July 4th-8th 2005: 8-12.
       
    • C.Vedruccio, Non-linear Resonance Interaction. The Trimprob clinical trials , Minimally Invasive Therapies & Novel Embedded Technology Systems, The Text Book of The 2st European Summer School (ARISER) IFC-CNR , Santa Cesarea Terme (Le)Italy, July 17th-21th 2006: 119-132.
       
    • C.Vedruccio, C.Ricci, The Trimprob Non Linear Resonance Interaction for early Cancer Detection, Casciaro S. and Samset E. (Eds.) 2007, Minimally Invasive Therapies and Novel Embedded Technologies, Lupiensis Biomedical Publications , Lecce, 2007:111-118.
       
    • C.Vedruccio, Non Linear Resonance Interaction. Some New Applications of the Trimprob for Cancer Detection on Stomach-Duodenum and Other Organs, Casciaro S. and Samset E. (Eds.), Minimally Invasive Therapies and Novel Embedded Technologies, Lupiensis Biomedical Publications, Lecce, 2007:22-26.
       
    • C.Vedruccio, Polarizability of normal and cancerous tissues, a Radiofrequency Nonlinear Resonance Interaction non invasive diagnostic Bioscanner Trimprob detector, in L. Giuliani, M. Soffritti (Eds). Non-thermal effects and mechanisms of interaction between electromagnetic fields and living matter, Mattioli 1885 spa, Fidenza, 2010: pagg.177-185. European Journal of Oncology - Library Vol. 5 (National Institute for the Study and Control of Cancer and Environmental Diseases “Bernardino Ramazzini” Bologna, Italy.
       
  •  Clinical trials related  scientific publications (not PUBMED indexed):

    • C. Vedruccio, E. Mascia, V. Martines, Ultra High Frequency and Microwave Non-linear Interaction Device for Cancer Detection and Tissue Characterization , a Military Research approach to prevent Health Diseases, International Review of the Armed Forces Medical Services (IRAFMS), vol 78/2: 120-126( 2005) .
      doc\Stomaco IRAFMS 2005.pdf

     

    • Bellorofonte et al., Il Trimpob: un nuovo mezzo diagnostico non invasivo nel carcinoma prostatico dell’anziano, Cancer and Aging, vol. 3 n.1: 31-36 (2005).
       
    • A.M. Lucisano, N. Innaro, F. Pata, R.Sacco, Diagnosis of Carcinoma in Multinodular Goiter by Electromagnetic Interactions. Preliminary Results. European Surgical Research 2006; 38:129-312.

     

  •  Divulgative publications
    ( To be completed)

     

    • Umberto Veronesi, La prostata? Per salvarla c’è un’arma in più.Mensile Oggi, n.5 febbraio 2006
      (A cura di Edoardo Rosati)
    • Settimanale "Oggi" del 5 febbraio 2006: doc\trimprobe Veronesi light.pdf   

    Intervista a Clarbruno Vedruccio a cura di Stefano Lorenzetto (Rubrica Tipi Italiani) su Il Giornale del 14 marzo 2010 dal titolo “Ha inventato la macchina che vede i tumori: lo accusano di stregoneria”. (IN PROGRESS)

    http://www.ilgiornale.it/interni/ha_inventato_macchina_che_vede_i_tumori_accusano_stregoneria/14-03-2010/articolo-id=429339-page=0-comments=2

    doc\Il Giornale 14 marzo 2010.pdf    

    http://www.lastampa.it/_web/CMSTP/tmplrubriche/giornalisti/grubrica.asp?ID_blog=124&ID_articolo=986&ID_sezione=274&sezione=    



     

    Research doctorate

    • Dott. Cosimo De Nunzio, Urologia, Università La Sapienza, Roma

    • Dott. Luca Ronci, Urologia, Università Alma Mater Studiorum, Bologna

    • Dott.ssa Ai Ling Romanò, Urologia, Università Statale, Milano

    • Dott. Filippo Calzolari, Chirurgia, Seconda Università, Napoli
     

    RESEARCH DOCTORATE IN PROGRESS

 

POSTERS AND  CONGRESS

M. Tufano, C. Vedruccio, Principi e applicazioni cliniche del TRIMprob in diagnostica. 41° Congresso Nazionale SIRM (Società Italiana per la Radiologia Medica), maggio 2004, Palermo.

L. D'Urso et al. Renal Cancer Detection with a New Non Invasive Diagnostic Tool (TRIMprob): A
SCUP Pilot Study. 19th EAU Meeting, Maggio 2004, Vienna

C. Bellorofonte et al. La Risonanza Elettromagnetica Non-Lineare nella Diagnostica delle Patologie
Prostatiche. 77° Congresso SIU, Giugno 2004, Milano

B. Rocco et al. Sensibilità e Valore Predittivo Negativo della Biopsia Prostatica ed Esperienza
Preliminare con TRIMprob. 77° Congresso SIU, Giugno 2004, Milano

V. Martines. TRIMprob: from Military Technology a Weapon for the Defense of Health. Preliminary
Report. 35th International Congress on Military Medicine, Settembre 2004, Washington

L. D'Urso et al. Diagnosi di Neoplasia Renale con un Nuovo Metodo Non Invasivo (TRIMprob): uno
Studio Pilota dello SCUP. 14° Congresso SIURO, Dicembre 2004, Trieste

R. Bartoletti et al. Significato dell’Esame TRIMprob nella Diagnostica dei Pazienti Affetti da
Carcinoma Prostatico Sottoposti a 2 o più Sequenze Bioptiche. 14° Congresso SIURO, Dicembre
2004, Trieste

G. Leucci et al. Studio Pilota per la Diagnosi del Carcinoma Vescicale mediante l’Utilizzo del
TRIMprob. Dati Preliminari. XI Congresso Nazionale AUROIT, Ottobre 2004, Lecce, e 6°
Congresso SUN, Novembre 2004, Bari

XI NATIONAL CONGRES AUROIT, LECCE, 6 – 9 OTTOBRE 2004: doc\Congr XI AURO vescica1 2004.pdf   
 


C. Bellorofonte et al. The Accuracy of the TRIMprob for the Diagnosis of Prostate Cancer: Two-
Year Experience. 20th EAU Meeting, Marzo 2005, Istanbul: PosterIstanbul.pdf  

C. Bellorofonte et al. The Accuracy of the TRIMprob for the Diagnosis of Prostate Cancer. AUA
2005 Annual Meeting, Maggio 2005, USA

A. Stoppacciaro et al. The Effect of the TRIMprob on the Patient Population Selected for Prostate
Biopsy and Biopsy Outcome. 78° Congresso SIU, Giugno 2005, Palermo

C. Rotondo et al. Utilizzo del TRIMprob nella Diagnosi del Carcinoma Vescicale: Esperienza
Preliminare. 15° Congresso SIURO, Novembre 2005, Giardini Naxos

A. Tubaro et al. Early Diagnosis of Prostate Cancer: TRIMprob versus PSA, DRE and TRUS: a
Toss-up Controlled Study. 21st EAU Meeting, Aprile 2006, Paris

L. Da Pozzo et al. Tissue Resonance Interaction Method for Non Invasive Diagnosis of Prostate
Cancer: A Multicenter Clinical Evaluation. 21st EAU Meeting, Aprile 2006, Paris

C. De Nunzio et al. TRIMprob, PSA, ER ed Ecografia nella Diagnosi del Tumore Prostatico. Studio
Clinico Controllato verso la Legge del Caso. 79° Congresso SIU, Giugno 2006, Bologna

L. Da Pozzo et al. Tissue Resonance Interaction Method nella Diagnosi Non Invasiva del
Carcinoma Prostatico: Risultati di uno Studio Prospettico Multicentrico. 79° Congresso SIU,
Giugno 2006, Bologna

A.M. Lucisano, N. Innaro, F. Pata, R. Sacco. Diagnosis of Carcinoma in Multinodular Goiter by
Electromagnetic Interactions. Preliminary Results. 19° Congresso Nazionale dell’Italian
Polyspecialist Society of Young Surgeons (IPSYS), Giugno 2006, Bologna

R. Sacco et al. TRIMprob, a New Diagnostic Tool in Cancer Detection. Workshop. 3rd Cancer
Conference of the African Oncology Institute, Gennaio 2007, Sabratha (Libia)

P. Cialone (Col.). Il Ruolo del TRIMprob nella Diagnosi del Carcinoma della Prostata. Focus on:
“Carcinoma della Prostata”. Attualità Diagnostiche e Terapeutiche, Marzo 2007, Roma

G. De Giorgi et al. Utilizzo del TRIMprob nella Diagnostica Non Invasiva del Tumore Prostatico.
80° Congresso SIU, Settembre 2007, Bari, e 17° Congresso SIURO, Novembre 2007, Modena

R. Ballario et al. TRIMprob e Biopsia Prostatica. Risultati di uno Studio Prospettico ‘Single Blind’.
XIV Congresso AUROIT, Ottobre 2007, Firenze, e 17° Congresso SIURO, Novembre 2007,
Modena
P. Viganò, G.R. Strada. TRIMprob nella Diagnostica Non Invasiva del Carcinoma Prostatico:
Esperienza Personale. 17° Congresso SIURO, Novembre 2007, Modena

A. Cicione, C. De Nunzio et al. TRIMprob for the Electromagnetic Detection of Prostate Cancer:
Accuracy Evaluation. 20° Congresso Nazionale dell’Italian Polyspecialist Society of Young
Surgeons (IPSYS), Novembre 2007, Napoli

F. Pata, A.M. Lucisano, D.P. Pafundi, R. Sacco. TRIMprob in Diagnosis of Bladder Cancer:
Preliminary Results. 20° Congresso Nazionale dell’Italian Polyspecialist Society of Young
Surgeons (IPSYS), Novembre 2007, Napoli

F. Carrozza. Possibile Utilizzo del TRIMprob nella Diagnostica del Cancro Mammario. Workshop
Oncologico Pratico Militare, Novembre 2007, Roma
http://www.icems.eu/docs/venice/6th_Workshop_Carrozza.pdf


A. Barbarisi et al. TRIMprob Radiation Interaction with Prostate Cells: Effect on Cellular Activity
and Implication for Carcinoma Diagnosis. 11° Conferenza Annuale dell’ESS (European Society of
Surgery), Novembre-Dicembre 2007, Krakow (Polonia)

 

Marcello Tufano: XVII National Congress of Digestive Diseases (Gastro-enterology), 5 to 9 March 2011, Torino, Poster Session: "The  Accuracy of the BIOSCANNER TRIMPROB®, a non-invasive tool, for the diagnosis of Colon Cancer. A Double blind prospective study".

doc\tufano_to2011.pdf

 

 

EXPERIMENTAL STUDY IN NUDE MICE  - "The Sapienza University", Dept. of Urology, Sant’Andrea Hospital, Rome, Italy, , Dept. of Pathology, Rome, Italy, National Cancer Institute “Regina Elena”, Laboratory for Preclinical Experimental Chemotherapy, Rome, Italy

Tubaro A.1, De Nunzio C.1, Stoppacciaro A.2, Leonetti C., Zupi G., Miano L.1
Ospedale Sant’Andrea, “La Sapienza University”, Dept. of Urology, Rome, Italy, 2Ospedale Sant’Andrea, “La Sapienza University”, Dept. of Pathology, Rome, Italy, National Cancer Institute “Regina Elena”, Laboratory for Preclinical Experimental Chemotherapy, Rome, Italy

830 - AN EXPERIMENTAL STUDY IN NUDE MICE ON THE ELECTROMAGNETIC DIAGNOSIS OF TUMOURS, Eur Urol Suppl 2008;7(3):278

Abstr 830-Tubaro mice 2008.pdf

Eur Urol.mice 2008.pdf


 

 

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Ultimo aggiornamento: 15 aprile 2013